U.S. Department of Energy

Pacific Northwest National Laboratory

Richard Smith

Biography:

Battelle Fellow and Chief Scientist within the Biological Sciences Division, Dr. Smith's research interests span development of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry, and their applications in biological and biomedical research. Over the last 20 years, much of Dr. Smith's research has centered on creating and applying new ultra-sensitive technologies to quantitatively probe entire proteomes expressed by cells, tissues, and organisms. More recently, these efforts have broadened to include development and application of highly sensitive, high-throughput technologies for measuring the ‘pan-ome’ (also including the metabolome, lipidome, and glycome) to augment biological research.

Dr. Smith also is Director of Proteome Research at PNNL, Director of the NIH Research Resource for Integrative Proteomics, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member at the University of Idaho. Dr. Smith completed his Ph.D. work in Physical Chemistry at the University of Utah.

Dr. Smith is the author/co-author of approximately 1000 peer-reviewed journal articles, is the recipient of 47 patents and 10 R&D 100 Awards.

Research Interests:
  • Development and application of advanced analytical methods and instrumentation, with particular emphasis on high resolution separations and mass spectrometry, and their applications in biological and biomedical research
  • Development and application of new ultra-sensitive methods for quantitatively probing the entire array of proteins expressed by a cell, tissue or organism, i.e., their “proteomes”
  • Increasing the throughput and sensitivity of proteomics and metabolomics measurements to augment systems biology research
Education:
  • Ph.D., Physical Chemistry, University of Utah
  • B.S., Chemistry, Lowell Technological Institute, University of Massachusetts
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