U.S. Department of Energy

Pacific Northwest National Laboratory

VIPER: an advanced software package to support high-throughput LC-MS peptide identification.

TitleVIPER: an advanced software package to support high-throughput LC-MS peptide identification.
Publication TypeJournal Article
Year of Publication2007
AuthorsMonroe ME, Tolić N, Jaitly N, Shaw JL, Adkins JN, Smith RD
JournalBioinformatics
KeywordsAlgorithms, Amino Acid Sequence, Chromatography, Liquid, Mass Spectrometry, Molecular Sequence Data, Peptide Mapping, Peptides, Sequence Analysis, Protein, Software, User-Computer Interface
Abstract

SUMMARY: The accurate mass and time (AMT) tag approach is used for analysis of large scale experiments by combining information generated over multiple datasets and instrument types. The VIPER software package is one of the key components of the data processing pipeline and implements automated algorithms to discover LC-MS features, align and match these LC-MS features to a database of peptides previously identified in LC-MS/MS analyses, and identify and quantify pairs of isotopically labeled peptides.

AVAILABILITY: VIPER may be downloaded free of charge at http://omics.pnl.gov/software/viper-1

DOI10.1093/bioinformatics/btm281
Alternate JournalBioinformatics
PubMed ID17545182
Grant ListRR018522 / RR / NCRR NIH HHS / United States
Y1-AI-4894-01 / AI / NIAID NIH HHS / United States
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