U.S. Department of Energy

Pacific Northwest National Laboratory

Unraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations

TitleUnraveling the isomeric heterogeneity of glycans: ion mobility separations in structures for lossless ion manipulations
Publication TypeJournal Article
Year of Publication2018
AuthorsNagy G., Attah I.K, Garimella S.VB, Tang K., Ibrahim Y.M, Baker E.S, Smith R.D
JournalChem. Commun. (Camb.)
Abstract

To address the challenges associated with glycan analyses, we have implemented a structures for lossless ion manipulations (SLIM) serpentine ultra-long path with extended routing (SUPER) ion mobility-mass spectrometry (i.e. SLIM SUPER IM-MS) platform to achieve much higher resolution of isomeric glycoforms. We have demonstrated the potential of this platform as a future component of the glycomics toolbox.

| Pacific Northwest National Laboratory