U.S. Department of Energy

Pacific Northwest National Laboratory

Rectangular ion funnel: a new ion funnel interface for structures for lossless ion manipulations.

TitleRectangular ion funnel: a new ion funnel interface for structures for lossless ion manipulations.
Publication TypeJournal Article
Year of Publication2015
AuthorsChen T-C, Webb IK, Prost SA, Harrer MB, Norheim RV, Tang K, Ibrahim YM, Smith RD
JournalAnal Chem
Abstract

Structures for lossless ion manipulations (SLIM) have recently demonstrated the ability for near lossless ion focusing, transfer, and trapping in subatmospheric pressure regions. While lossless ion manipulations are advantageously applied to the applications of ion mobility separations and gas phase reactions, ion introduction through ring electrode ion funnels or more conventional ion optics to SLIM can involve discontinuities in electric fields or other perturbations that result in ion losses. In this work, we developed and investigated a new funnel design that aims to seamlessly couple to SLIM at the funnel exit. This rectangular ion funnel (RIF) was initially evaluated by ion simulations, fabricated utilizing printed circuit board technology, and tested experimentally. The RIF was integrated to a SLIM-time of flight (TOF) MS system, and the operating parameters, including RF, DC bias of the RIF electrodes, and electric fields for effectively interfacing with a SLIM, were characterized. The RIF provided a 2-fold sensitivity increase without significant discrimination over a wide m/z range and well matched to that of SLIM, along with greatly improved SLIM operational stability.

DOI10.1021/ac503564c
Alternate JournalAnal. Chem.
PubMed ID25409343
PubMed Central IDPMC4287841
Grant ListP41 GM103493 / GM / NIGMS NIH HHS / United States
P41 GM103493 / GM / NIGMS NIH HHS / United States
Area of Research: 
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