U.S. Department of Energy

Pacific Northwest National Laboratory

Mobility-resolved ion selection in uniform drift field ion mobility spectrometry/mass spectrometry: dynamic switching in structures for lossless ion manipulations.

TitleMobility-resolved ion selection in uniform drift field ion mobility spectrometry/mass spectrometry: dynamic switching in structures for lossless ion manipulations.
Publication TypeJournal Article
Year of Publication2014
AuthorsWebb IK, Garimella SVB, Tolmachev AV, Chen T-C, Zhang X, Cox JT, Norheim RV, Prost SA, LaMarche B, Anderson GA, Ibrahim YM, Smith RD
JournalAnal Chem
KeywordsMass Spectrometry, Molecular Structure
Abstract

A Structures for Lossless Ion Manipulations (SLIM) module that allows ion mobility separations and the switching of ions between alternative drift paths is described. The SLIM switch component has a "Tee" configuration and allows the efficient switching of ions between a linear path and a 90-degree bend. By controlling switching times, ions can be efficiently directed to an alternative channel as a function of their mobilities. In the initial evaluation the switch is used in a static mode and shown compatible with high performance ion mobility separations at 4 Torr. In the dynamic mode, we show that mobility-selected ions can be switched into the alternative channel, and that various ion species can be independently selected based on their mobilities for time-of-flight mass spectrometer (TOF MS) IMS detection and mass analysis. This development also provides the basis of, for example, the selection of specific mobilities for storage and accumulation, and the key component of modules for the assembly of SLIM devices enabling much more complex sequences of ion manipulations.

DOI10.1021/ac502139e
Alternate JournalAnal. Chem.
PubMed ID25222548
PubMed Central IDPMC4188271
Grant ListP41 GM103493 / GM / NIGMS NIH HHS / United States
P41 GM103493 / GM / NIGMS NIH HHS / United States
Area of Research: 
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