U.S. Department of Energy

Pacific Northwest National Laboratory

Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics

TitleIdentification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics
Publication TypeJournal Article
Year of Publication2017
AuthorsNielson C.M, Wiedrick J., Shen J., Jacobs J., Baker E.S, Baraff A., Piehowski P., Lee C.G, Baratt A., Petyuk V., McWeeney S., Lim J.Y, Bauer D.C, Lane N.E, Cawthon P.M, Smith R.D, Lapidus J., Orwoll E.S
JournalJ. Bone Miner. Res.
Abstract

{Serum proteomics analysis may lead to the discovery of novel osteoporosis biomarkers. The Osteoporotic Fractures in Men (MrOS) study comprises men ≥65 years old in the US who have had repeated BMD measures and have been followed for incident fracture. High-throughput quantitative proteomic analysis was performed on baseline fasting serum samples from non-Hispanic white men using a multidimensional approach coupling liquid chromatography, ion-mobility separation, and mass spectrometry (LC-IMS-MS). We followed the participants for a mean of 4.6 years for changes in femoral neck bone mineral density (BMD) and for incident hip fracture. Change in BMD was determined from mixed effects regression models taking age and weight into account. Participants were categorized into three groups: BMD maintenance (no decline; estimated change ≥0 g/cm2

| Pacific Northwest National Laboratory