U.S. Department of Energy

Pacific Northwest National Laboratory

DAnTE: a statistical tool for quantitative analysis of -omics data.

TitleDAnTE: a statistical tool for quantitative analysis of -omics data.
Publication TypeJournal Article
Year of Publication2008
AuthorsPolpitiya AD, Qian W-J, Jaitly N, Petyuk VA, Adkins JN, Camp DG, Anderson GA, Smith RD
JournalBioinformatics
KeywordsAlgorithms, Data Interpretation, Statistical, Databases, Protein, Peptide Mapping, Proteome, Proteomics, Software
Abstract

UNLABELLED: Data Analysis Tool Extension (DAnTE) is a statistical tool designed to address challenges associated with quantitative bottom-up, shotgun proteomics data. This tool has also been demonstrated for microarray data and can easily be extended to other high-throughput data types. DAnTE features selected normalization methods, missing value imputation algorithms, peptide-to-protein rollup methods, an extensive array of plotting functions and a comprehensive hypothesis-testing scheme that can handle unbalanced data and random effects. The graphical user interface (GUI) is designed to be very intuitive and user friendly.

AVAILABILITY: DAnTE may be downloaded free of charge at http://omics.pnl.gov/software/.

SUPPLEMENTARY INFORMATION: An example dataset with instructions on how to perform a series of analysis steps is available at http://omics.pnl.gov/software/

DOI10.1093/bioinformatics/btn217
Alternate JournalBioinformatics
PubMed ID18453552
PubMed Central IDPMC2692489
Grant ListP41 RR018522-05 / RR / NCRR NIH HHS / United States
P41 RR018522-06 / RR / NCRR NIH HHS / United States
RR18522 / RR / NCRR NIH HHS / United States
U54 GM-62119-02 / GM / NIGMS NIH HHS / United States
U54 GM062119 / GM / NIGMS NIH HHS / United States
Y1-AI-4894-01 / AI / NIAID NIH HHS / United States
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