We investigate diverse and cutting edge biological research questions using extensive separations and mass spectrometry (MS) capabilities at Pacific Northwest National Laboratory (PNNL), with an emphasis on proteomics, and metabolomics and other MS-based ‘pan-omics’ measurements. Many of these capabilities with associated bioinformatics algorithms have been developed at PNNL and are housed in the Department of Energy's Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility. Most of the capabilities have been developed and/or acquired through support from DOE’s Office of Biological and Environmental Research to the EMSL, as well as DOE-supported PNNL programmatic research, the NIH supported P41 Proteomics Research Resource, and other NIH programs.
The state-of-the-art core MS capabilities for proteomics and pan-omics are supported and facilitated by a range of advanced separations capabilities (e.g., involving electrophoresis, chromatography and ion mobility). Particular strengths are applications involving very small samples sizes, and in high-throughput applications involving the analysis of very large numbers of samples. These capabilities are further supported by laboratories equipped for high-throughput sample preparation and storage, chemical synthesis and derivatization, as well as extensive resources for supporting biochemical and molecular biology research. The separations and MS-based research continually generates large volumes of data, and significant resources are devoted to capabilities for the management, storage, analysis, integration, and interpretation of the large datasets produced.
Using the Site
This site is organized around the publications authored by PNNL researchers and their collaborators providing public access to the data, software, and supplemental materials generated from those publications. Additionally, data and software resources are hosted in community supported repositories.
All publications that result from the use of information from this center should include an acknowledgment as found in the primary literature publication.